Growth of Venezuelan equine encephalomyelitis virus in human diploid cell strain WI-38.
نویسندگان
چکیده
We demonstrated that Venezuelan equine encephalomyelitis (VEE) virus replicated in and adapted rapidly to human diploid cell strain WI-38. Peak titers of approximately 10(9.8) mouse intracerebral 50% lethal doses were obtained at low passage levels in Eagles basal medium supplemented with calf serum. VEE virus replicated poorly in serum-free medium. Propagation of VEE virus was accompanied by the production of hemagglutinin and cytopathogenic effects.
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ورودعنوان ژورنال:
- Applied microbiology
دوره 19 1 شماره
صفحات -
تاریخ انتشار 1970